Some medications and supplements can harm the kidneys, especially if taken in high doses, for long periods, or without medical supervision. But you should not stop prescribed medication suddenly based only on a headline.
Common medicines that can affect the kidneys
Pain relievers (NSAIDs)
Examples:
- Ibuprofen
- Naproxen
These can reduce blood flow to the kidneys, especially with dehydration or long-term heavy use.
Some antibiotics
Certain antibiotics may stress the kidneys in some people, especially at high doses or with existing kidney disease.
Some acid reflux medicines
Long-term use of certain proton pump inhibitors (PPIs) has been linked to kidney problems in some studies.
High-dose supplements or herbal products
Examples:
- very high-dose vitamin C,
- some bodybuilding supplements,
- or unregulated herbal mixtures.
Some diabetes or blood pressure medicines
These are often safe and helpful when monitored correctly, but doctors may adjust them if kidney function changes.
Risk factors for kidney damage
- Dehydration
- Taking several medicines together
- Existing kidney disease
- Older age
- Taking more than directed
Possible warning signs
- Swelling
- Reduced urination
- Fatigue
- Nausea
- Foamy urine
Important
Never stop prescription medicine without talking to a doctor or pharmacist first. Many medications are safe when used properly and monitored.
Reliable medication information:

