Headlines like “23 Strange Signs Your Kidneys Might Be in Trouble” often mix real symptoms with vague ones that can be caused by many different conditions.
The kidneys help filter waste, balance fluids, and regulate blood pressure. When they’re not working properly, some possible warning signs can include:
More common signs
- Swelling in the feet, ankles, legs, or around the eyes
- Changes in urination (more, less, darker, foamy, or bloody urine)
- Persistent fatigue or weakness
- Nausea or loss of appetite
- High blood pressure that is difficult to control
Other symptoms that can occur
- Muscle cramps
- Itchy skin
- Trouble concentrating
- Shortness of breath (especially if fluid builds up)
- Puffiness around the eyes
- Difficulty sleeping
Important caution
Many of these symptoms are not unique to kidney disease. For example, fatigue, swelling, or cramps can have numerous causes.
When to seek medical attention
See a healthcare professional if you have:
- Blood in your urine
- Significant swelling
- Persistent changes in urination
- Unexplained high blood pressure
- Symptoms that are worsening or not improving
Because kidney disease can be silent in its early stages, simple tests such as urine tests and blood tests are often needed to determine whether the kidneys are healthy.
Chronic kidney disease is often easier to manage when detected early.

