A headline like “Eight pills you shouldn’t take because they damage your kidneys” is usually misleading. Many medications can affect the kidneys, but that doesn’t mean nobody should take them. The key issues are dose, duration, existing kidney disease, dehydration, and medical supervision.
Medications that can affect kidney function
1. Ibuprofen
Can reduce blood flow to the kidneys, especially in people with kidney disease, heart failure, or dehydration.
2. Naproxen
Similar kidney-related risks to ibuprofen.
3. Diclofenac
Another NSAID that may affect kidney function, particularly with long-term use.
4. Celecoxib
Can affect the kidneys in susceptible individuals.
5. Certain antibiotics
Some antibiotics require dose adjustments in people with kidney disease.
6. Certain diuretics (“water pills”)
These can contribute to dehydration and electrolyte imbalances if not used appropriately.
7. Some acid-reducing medications
Long-term use of some drugs in this category has been associated with kidney problems in some studies.
8. Some antiviral, chemotherapy, and immunosuppressive medications
These may require close monitoring because they can affect kidney function.
Higher-risk situations
Kidney injury is more likely if a person:
- Already has kidney disease.
- Is dehydrated.
- Is older.
- Takes multiple medications that affect the kidneys.
- Has diabetes or heart failure.
Warning signs of possible kidney problems
Contact a healthcare professional if you experience:
- Reduced urination.
- Swelling of the legs, ankles, or feet.
- Unexplained fatigue.
- Shortness of breath.
- Persistent nausea.
Important: Don’t stop prescribed medication on your own
Many medications that can affect the kidneys are still very beneficial when used appropriately. If you’re concerned about kidney risk, discuss it with your doctor or pharmacist rather than stopping treatment abruptly.
The biggest concern for many otherwise healthy people is the frequent or long-term use of NSAIDs such as ibuprofen and naproxen, especially when dehydrated or when underlying kidney disease is present.
